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The New England Journal of Medicine: Search Results
The New England Journal of Medicine (NEJM) RSS feed -- Search Results. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

National Coverage Analysis of CAR-T Therapies ? Policy, Evidence, and Payment
31/12/69 - In December 2017, the Boston radio station WBUR chronicled the case of the first patient at Massachusetts General Hospital to receive axicabtagene ciloleucel (Yescarta, Gilead) outside a clinical trial. The chimeric antigen receptor T cells (CAR-Ts) were made from 71-year-old Barbara Kearney?s own…

The Next Phase of Human Gene-Therapy Oversight
31/12/69 - The National Institutes of Health (NIH) and the Food and Drug Administration (FDA) have played key roles in the emergence of safe and effective human gene therapies. Now, we are proposing new efforts to encourage further advances in this rapidly evolving field. The potential to alter human genes…

"Precision" Public Health ? Between Novelty and Hype
31/12/69 - In May 2018, the National Institutes of Health (NIH) began enrollment for a vast medical research cohort. Named "All of Us," it?s meant to include 1 million U.S. volunteers, who will be studied over 10 years at a cost of $1.45 billion. The project promises to "lay the scientific foundation for a…

Case 31-2018: A 37-Year-Old Man with a Self-Inflicted Gunshot Wound
31/12/69 - Presentation of Case. Dr. Jordan P. Bloom (Surgery): A 37-year-old man was admitted to the surgical intensive care unit (ICU) of this hospital because of a self-inflicted gunshot wound. The patient had been in his usual state of health until 2 days before admission. That evening, while he was at…

Allogeneic BK Virus?Specific T Cells for Progressive Multifocal Leukoencephalopathy
31/12/69 - Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating infection of the central nervous system caused by reactivation of the JC polyomavirus that occurs in the context of defective cellular immunity. Common underlying conditions that are associated with JC virus infection include…

Classification, Ontology, and Precision Medicine
31/12/69 - A goal of precision medicine is to stratify patients in order to improve diagnosis and medical treatment. Translational investigators are bringing to bear ever greater amounts of heterogeneous clinical data and scientific information to create classification strategies that enable the matching of…

Real-Time Patient?Provider Video Telemedicine Integrated with Clinical Care
31/12/69 - To the Editor: Telemedicine by means of video visits can increase patient access to care, but there is little evidence about broad integration of video visits into existing clinical care, particularly for primary care. In an integrated delivery system that implemented video-visit capability for all…

Informed Consent and the Role of the Treating Physician
31/12/69 - To the Editor: I agree with the call of Fernandez Lynch and colleagues (June 21 issue) for a collaborative approach to informed consent while maintaining the central roles of the treating doctor and the patient. Rendering informed consent a nondelegable responsibility in the United States could…

Endovenous Ablation in Venous Ulceration
31/12/69 - To the Editor: We acknowledge that the Early Venous Reflux Ablation (EVRA) trial by Gohel et al. (May 31 issue) will undoubtedly play a role in changing management practices for this frequently neglected patient cohort, although we wish to make two points. First, whereas previous studies have…

Classification and Personalized Prognosis in Myeloproliferative Neoplasms
31/12/69 - Myeloproliferative neoplasms are clonal hematopoietic disorders comprising polycythemia vera, which is characterized by red-cell overproduction; essential thrombocythemia, which involves elevated platelet counts; and myelofibrosis, which is defined by bone marrow fibrosis. Polycythemia vera and…

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