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The New England Journal of Medicine: Search Results in Neurology\Neurosurgery
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Neurology\Neurosurgery. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Case 15-2018: An 83-Year-Old Woman with Nausea, Vomiting, and Confusion
31/12/69 - Presentation of Case. Dr. Andrew S. Hoekzema (Medicine): An 83-year-old woman was admitted to this hospital in the winter because of nausea, vomiting, diarrhea, and confusion. One week before admission, rhinorrhea, sore throat, and nonproductive cough developed. The patient felt feverish but did…

Effect of Cannabidiol on Drop Seizures in the Lennox?Gastaut Syndrome
31/12/69 - The Lennox?Gastaut syndrome is a severe developmental epileptic encephalopathy that has multiple causes and an incidence of approximately two cases per 100,000 population. The disorder is characterized by several seizure types, severe cognitive impairment, and an abnormal electroencephalographic…

Study of Intraventricular Cerliponase Alfa for CLN2 Disease
31/12/69 - Neuronal ceroid lipofuscinosis type 2 (CLN2) disease, a form of Batten?s disease, is a rare, autosomal recessive, pediatric neurodegenerative disease resulting from pathogenic variants in the gene encoding lysosomal enzyme tripeptidyl peptidase 1 (TPP1). A deficiency of TPP1 results in accumulation…

Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA
31/12/69 - The risk of ischemic stroke ranges from 3 to 15% in the 90 days after a minor ischemic stroke or a transient ischemic attack (TIA). In several trials, aspirin has been shown to reduce the risk of recurrent stroke by approximately 20%. Clopidogrel blocks platelet aggregation through the…

Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source
31/12/69 - Ischemic strokes of uncertain cause, also called cryptogenic strokes, are frequent despite advances in the diagnostic techniques used to determine the underlying cause and to implement treatment specific to their causes. Most cryptogenic strokes are presumed to result from emboli originating from…

MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset
31/12/69 - Intravenous thrombolysis with alteplase, a recombinant tissue plasminogen activator, is the standard medical treatment for acute ischemic stroke within 4.5 hours after the onset of symptoms. In 14 to 27% of strokes, the time of symptom onset is not known, frequently because stroke symptoms are…

Five-Year Risk of Stroke after TIA or Minor Ischemic Stroke
31/12/69 - With urgent diagnosis and management of transient ischemic attack (TIA) and minor ischemic stroke and a reduction of risk factors during the past decades, the risk of stroke and other vascular events and stroke has been reduced. In previous reports involving patients enrolled in stroke registries…

Antiplatelet Therapy after Ischemic Stroke or TIA
31/12/69 - Antiplatelet therapy is the mainstay for the prevention of primary stroke in patients with risk factors and for the prevention of recurrent stroke after transient ischemic attack (TIA) or ischemic stroke. An outstanding question concerns appropriate antiplatelet regimens under various clinical…

MRI-Guided Intravenous Alteplase for Stroke ? Still Stuck in Time
31/12/69 - Time is a critical determinant of patient eligibility for intravenous thrombolysis in acute stroke. In such patients, intravenous alteplase is routinely administered up to 4.5 hours after the onset of symptoms, but even within this window, earlier treatment leads to better outcomes. Restriction of…

Essential Tremor
31/12/69 - This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors? clinical recommendations. A 62-year-old woman presents…

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