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The New England Journal of Medicine: Search Results in Neurology\Neurosurgery
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Neurology\Neurosurgery. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Circulating Extracellular Vesicles in Human Disease
31/12/69 - It is well known that cells release fluid-filled sacs (vesicles) to the extracellular environment during cell death, or apoptosis, but it has been increasingly recognized that healthy cells may also release vesicles in the process of normal functions. Vesicles that are released by healthy cells…

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis
31/12/69 - Even though more than a dozen therapies have been approved for the treatment of relapsing forms of multiple sclerosis, only the monoclonal antibody ocrelizumab and the chemotherapy agent mitoxantrone are approved for progressive multiple sclerosis. Ibudilast is a small molecule available in Asia…

Case 27-2018: A 3-Year-Old Boy with Seizures
31/12/69 - Presentation Of Case. Dr. Caitlin E. Naureckas Li (Pediatrics): A 3-year-old boy was admitted to this hospital during the summer because of a seizure. The patient had been well until 3 days before admission, when one episode of emesis occurred. The following evening, he was fussy, and on the third…

Immunotherapy for Melanoma Metastatic to the Brain
31/12/69 - Most practicing physicians will recall from their training that the average prognosis for patients with central nervous system (CNS) metastases from melanoma was death within a matter of weeks to months. This reflected the natural history of a disease on which systemic treatment had a negligible…

Free Drug Samples and the Opioid Crisis
31/12/69 - To the Editor: Malpractice on the part of some pharmaceutical companies has been established as a key driver of the opioid crisis. Powerful painkillers are offered under attractive conditions to poorly educated patients who are not aware of the risk of addiction and who eventually die from drug…

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain
31/12/69 - Brain metastases are a common complication of solid tumors and remain a major cause of disabling neurologic complications and death in patients with cancer. Among primary cancers in adults, melanoma has one of the highest propensities to metastasize to the brain. More than one third of patients…

MRI-Guided Intravenous Alteplase for Stroke ? Still Stuck in Time
31/12/69 - Time is a critical determinant of patient eligibility for intravenous thrombolysis in acute stroke. In such patients, intravenous alteplase is routinely administered up to 4.5 hours after the onset of symptoms, but even within this window, earlier treatment leads to better outcomes. Restriction of…

Parenteral Opioid Shortage ? Treating Pain during the Opioid-Overdose Epidemic
31/12/69 - The opioid-overdose epidemic now causes more than 30,000 deaths per year in the United States. In response to the increasing death toll, many measures have recently been implemented, including reclassification of hydrocodone as a Schedule II opioid and new requirements for physician review of…

MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset
31/12/69 - Intravenous thrombolysis with alteplase, a recombinant tissue plasminogen activator, is the standard medical treatment for acute ischemic stroke within 4.5 hours after the onset of symptoms. In 14 to 27% of strokes, the time of symptom onset is not known, frequently because stroke symptoms are…

Behind Schedule ? Reconciling Federal and State Marijuana Policy
31/12/69 - The long-standing chasm between federal and state marijuana policy recently widened when U.S. Attorney General Jeff Sessions rescinded Obama-era guidance indicating that the Justice Department would not make it a priority to prosecute federal marijuana crimes in states where the activities are…

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