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The New England Journal of Medicine: Search Results in Gastroenterology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Gastroenterology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Association of Changes in Diet Quality with Total and Cause-Specific Mortality
31/12/69 - Some epidemiologic studies of nutrition focus on dietary patterns rather than single nutrients or foods to evaluate the association between diet and health outcomes. Accumulated evidence supports an association between healthy dietary patterns and a decreased risk of death. Results from recent…

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis
31/12/69 - Genetic inquiry has contributed to our understanding of gastrointestinal diseases, associating at least 64 genes with early-onset or very-early-onset inflammatory bowel disease. Deleterious gene variants affect the intestinal epithelial barrier, phagocytosis processes, immune regulation, and…

Loss of CD55 in Eculizumab-Responsive Protein-Losing Enteropathy
31/12/69 - To the Editor: Protein-losing enteropathy usually manifests as peripheral and visceral edema due to hypoalbuminemia. We followed a large consanguineous Muslim?Arab family that included six patients who had protein-losing enteropathy associated with hypercoagulability (Fig. S1A in the Supplementary…

Irritable Bowel Syndrome
31/12/69 - The irritable bowel syndrome (IBS) is a chronic and sometimes disabling functional bowel disorder. Traditionally, this functional diagnostic label has been applied when no obvious structural or biochemical abnormalities are found, but emerging evidence suggests that distinct pathophysiological…

Trial of Transplantation of HCV-Infected Kidneys into Uninfected Recipients
31/12/69 - To the Editor: Waiting times for kidney transplants exceed 3 to 5 years in many parts of the United States. Yet more than 500 high-quality kidneys from deceased donors with hepatitis C virus (HCV) infection are discarded annually. Direct-acting antiviral agents, which are associated with high HCV…

Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection
31/12/69 - The majority of patients who are chronically infected with hepatitis C virus (HCV) can now be successfully treated with drugs that directly target viral replication. Combination regimens of direct-acting antiviral agents (DAAs) provide rates of sustained virologic response exceeding 90%, regardless…

Reversal of Autoimmune Toxicity and Loss of Tumor Response by Interleukin-17 Blockade
31/12/69 - To the Editor: Patients with autoimmune diseases have typically been excluded from immunotherapy clinical trials, although recent evidence suggests that the benefits of checkpoint therapy may outweigh the risks of autoimmune flare-ups in carefully selected patients who have a high probability of…

IDH2 Mutation in a Patient with Metastatic Colon Cancer
31/12/69 - To the Editor: Detection of circulating tumor DNA (ctDNA) in cell-free DNA (cfDNA) is an emerging noninvasive strategy for tumor profiling. However, an understanding of potential biologic interference associated with this new technique is still evolving. Here, we present a case that posed a…

Case 14-2017: A 20-Year-Old Man with Pain and Swelling of the Left Calf and a Purpuric Rash
31/12/69 - Presentation of Case. Dr. Lauren R. Zeitels (Medicine): A 20-year-old man was seen in an outpatient clinic of this hospital because of pain and swelling of the left calf and a purpuric rash. The patient had been well until 3 weeks before presentation to this hospital, when sore throat,…

Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis
31/12/69 - Ulcerative colitis is characterized by an increased frequency of bowel movements and bloody diarrhea, which has a negative effect on quality of life. Current therapies for ulcerative colitis include mesalamine, glucocorticoids, thiopurines, and antagonists to tumor necrosis factor (TNF) and ?4?7…

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