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The New England Journal of Medicine: Search Results in Pulmonary\Critical Care
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pulmonary\Critical Care. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection
31/12/69 - The overuse of antibiotic agents is a public health problem associated with increased health care costs and antibiotic resistance. Overuse of antibiotics is common in infections of the lower respiratory tract, where bacterial and viral infections manifest similarly. Procalcitonin is a peptide with…

Epigenetic Control of Interleukin-9 in Asthma
31/12/69 - Interleukin-9 is a pleiotropic cytokine associated with allergic inflammation and is a therapeutic target in patients with asthma. Its expression and that of the interleukin-9 receptor are greater in the lungs of persons with asthma than in those of healthy persons. In murine models of allergic…

Ultrasound-Guided Cannulation of the Subclavian Vein
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Combined Analysis of Asthma Safety Trials of Long-Acting ?2-Agonists
31/12/69 - Because of concerns about the safety of long-acting ?2-agonists (LABAs) in asthma management, the Food and Drug Administration (FDA) in 2010 issued a public health advisory stating that LABAs should not be used as first-line therapy for asthma, and a boxed warning was required for all products…

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma
31/12/69 - An estimated 45% of patients with severe asthma use systemic glucocorticoids to control the disease and prevent exacerbations. However, systemic glucocorticoids act nonselectively and are associated with considerable multiorgan toxic effects and broad immunosuppression. The use of the currently…

Prophylaxis against Upper Gastrointestinal Bleeding in Hospitalized Patients
31/12/69 - Beginning approximately four decades ago, a series of randomized trials suggested that, in seriously ill hospitalized patients, primary prevention of clinically important upper gastrointestinal bleeding ? stress-ulcer prophylaxis ? significantly reduces the risk of bleeding. In response, practice…

New Biologics for Asthma
31/12/69 - Two articles now published in the Journal indicate that dupilumab, a monoclonal antibody directed against the alpha subunit of the interleukin-4 receptor that inhibits interleukin-4 and interleukin-13 signaling, has a salutary treatment effect in severe asthma. In the first trial, patients with…

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
31/12/69 - Approximately 20% of patients with asthma have uncontrolled, moderate-to-severe disease with recurrent exacerbations and persistent symptoms despite maximized standard-of-care controller therapy. This population is at an increased risk for illness (especially exacerbations) and accounts for…

Inhaled Corticosteroids and LABAs ? Removal of the FDA?s Boxed Warning
31/12/69 - For years, the risks associated with the use of long-acting beta-agonists (LABAs) in patients with asthma have been uncertain, and some health care professionals have recommended conducting large clinical trials to gather important safety information on these products. In December 2017, the Food…

Stemming Lung Disease?
31/12/69 - Easy breathing depends on the millions of delicate, air-filled sacs, known as alveoli, that are the site of gaseous exchange in the lungs. Each alveolus is composed of two distinct epithelial cell types: cuboidal epithelial type 2 (AT2) cells, specialized to produce surfactant proteins, and very…

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