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The New England Journal of Medicine: Search Results in Pulmonary\Critical Care
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pulmonary\Critical Care. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis
31/12/69 - Clinically apparent brain injuries occur in 0.5 to 0.9% of episodes of diabetic ketoacidosis in children; these brain injuries manifest as sudden neurologic decline and are often associated with morbidity and mortality. Among patients without obvious neurologic decline during treatment for diabetic…

Substitute Decision Making in End-of-Life Care
31/12/69 - Three days ago, you were called to the intensive care unit (ICU) to examine Ms. Smith, a 70-year-old woman who had presented to the emergency department earlier that day with progressive shortness of breath. Ms. Smith had reported fatigue, progressive dyspnea, and intermittent fevers over the…

Case 18-2018: A 45-Year-Old Woman with Hypertension, Fatigue, and Altered Mental Status
31/12/69 - Presentation of Case. Dr. Sally A. Ingham (Medicine): A 45-year-old woman was admitted to this hospital because of dyspnea on exertion, fatigue, and confusion. The patient had been in her usual state of health until 18 months before the current admission, when the blood pressure was noted to be…

Fluid Composition, Infusion Rate, and Brain Injury in Diabetic Ketoacidosis
31/12/69 - Diabetic ketoacidosis constitutes a profound metabolic disturbance of energy homeostasis with a distinct biochemical profile that is characterized by hyperglycemia, ketonemia, metabolic acidosis, and electrolyte abnormalities. It is caused by deficiency of insulin, the hallmark of type 1 diabetes…

Infantile Pulmonary Teratoid Tumor
31/12/69 - To the Editor: Pulmonary blastoma, an uncommon lung tumor with both epithelial and mesenchymal components, is typically diagnosed in mid-to-late adulthood. Although it is rare in children, it should be distinguished from pleuropulmonary blastoma, a mesenchymal tumor. Pleuropulmonary blastomas and…

31/12/69 - A 44-year-old woman presented to the emergency department with acute chest pain after several months of progressive dyspnea. Her oxygen saturation was 92% while she was breathing ambient air, and the physical examination was notable for diminished breath sounds on the right side. Computed…

Pembrolizumab plus Chemotherapy in Metastatic Non?Small-Cell Lung Cancer
31/12/69 - Inhibitors of programmed death 1 (PD-1) and its ligand PD-L1 are effective therapies for metastatic non?small-cell lung cancer (NSCLC) lacking sensitizing EGFR or ALK mutations. Pembrolizumab (Keytruda, Merck), nivolumab (Opdivo, Bristol-Myers Squibb), and atezolizumab (Tecentriq, Genentech) are…

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden
31/12/69 - Standard-of-care therapy for previously untreated advanced non?small-cell lung cancer (NSCLC) without treatable driver mutations includes platinum-based chemotherapy and pembrolizumab for patients with a high level (?50%) of tumor programmed death ligand 1 (PD-L1) expression. There remains a need…

A New Standard of Care for Advanced Lung Cancer
31/12/69 - In 1995, the Non-small Cell Lung Cancer Collaborative Group published a landmark meta-analysis involving eight randomized trials that compared chemotherapy with no therapy or best supportive care for the first-line treatment of metastatic non?small-cell lung cancer (NSCLC). This meta-analysis not…

ICU Admissions for Sepsis or Pneumonia in Australia and New Zealand in 2017
31/12/69 - To the Editor: Seasonal patterns of presentations to intensive care units (ICUs) in the Southern Hemisphere can inform health care planning for critically ill patients worldwide, as was seen during the H1N1 influenza pandemic in 2009. During the late winter and early spring of 2017, ICUs in…

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