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The New England Journal of Medicine: Search Results in Genetics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Genetics. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
31/12/69 - Angiopoietin-like proteins (ANGPTLs) have been established as important regulators of lipoprotein metabolism and have thus emerged as attractive targets for modulation of lipid levels and cardiovascular disease risk. Loss-of-function variants in ANGPTL4, a negative regulator of lipoprotein lipase…

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides
31/12/69 - Despite advances in the development of lipid-lowering therapies, clinical trials have shown that a substantial risk of cardiovascular disease persists after currently recommended medical therapy. For example, in one trial involving patients who had had an acute coronary syndrome, the lowering of…

ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia
31/12/69 - To the Editor: Homozygous familial hypercholesterolemia is characterized by profound genetic deficiencies in the low-density lipoprotein (LDL) receptor pathway; patients with the condition who are not receiving lipid-lowering therapy have LDL cholesterol levels in the range of 500 to 1000 mg per…

Preventing Fat Gain by Blocking Follicle-Stimulating Hormone
31/12/69 - In a recent report, Liu and colleagues presented evidence that follicle-stimulating hormone (FSH) influences thermogenesis and adiposity in mice. They had reported previously that a polyclonal antibody that targets the beta subunit of FSH diminished ovariectomy-induced bone loss in mice. In the…

Increasing Lipolysis and Reducing Atherosclerosis
31/12/69 - In patients with coronary artery disease, residual cardiovascular risk remains substantial even after levels of low-density lipoprotein (LDL) cholesterol have been effectively lowered by treatment with statins, ezetimibe, or antibodies targeting proprotein convertase subtilisin?kexin type 9…

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
31/12/69 - Aging is associated with an increased incidence of cancer and cardiovascular disease. We and others recently used whole-exome sequencing data to identify a common, age-related disorder marked by an expansion of hematopoietic clones carrying recurrent somatic mutations, most frequently…

Amyotrophic Lateral Sclerosis
31/12/69 - Amyotrophic lateral sclerosis (ALS) is a progressive, paralytic disorder characterized by degeneration of motor neurons in the brain and spinal cord. It begins insidiously with focal weakness but spreads relentlessly to involve most muscles, including the diaphragm. Typically, death due to…

CHIP-ping Away at Atherosclerosis
31/12/69 - Efforts at prevention of cardiovascular disease hinge on the concept of risk factors that, when treated, attenuate the incidence of the disease. Since the concept of cardiovascular risk factors was first proposed in the Framingham Heart Study, many distinct risk algorithms have been developed to…

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis
31/12/69 - Genetic inquiry has contributed to our understanding of gastrointestinal diseases, associating at least 64 genes with early-onset or very-early-onset inflammatory bowel disease. Deleterious gene variants affect the intestinal epithelial barrier, phagocytosis processes, immune regulation, and…

Undermining Genetic Privacy? Employee Wellness Programs and the Law
31/12/69 - Genetic information is becoming ubiquitous in research and medicine. The cost of genetic analysis continues to fall, and its medical and personal value continues to grow. Anticipating this age of genetic medicine, policymakers passed laws and regulations years ago to protect Americans? privacy and…

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