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The New England Journal of Medicine: Search Results in Genetics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Genetics. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

The Next Phase of Human Gene-Therapy Oversight
31/12/69 - The National Institutes of Health (NIH) and the Food and Drug Administration (FDA) have played key roles in the emergence of safe and effective human gene therapies. Now, we are proposing new efforts to encourage further advances in this rapidly evolving field. The potential to alter human genes…

Update on Keratinocyte Carcinomas
31/12/69 - Basal-cell carcinoma and cutaneous squamous-cell carcinoma are the most common skin cancers worldwide. Although the term "nonmelanoma skin cancer" has traditionally been used to refer to all skin cancers except melanoma, "keratinocyte carcinoma" is becoming the preferred term for basal-cell…

Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema
31/12/69 - Hereditary angioedema is a genetic disorder characterized by recurrent episodes of swelling. Oropharyngeal swelling can be life-threatening, and attacks in other sites, including the limbs, genitalia, face, and intestines, can be painful, disabling, and disfiguring and have a substantial effect on…

Tipping Clonal Hematopoiesis into Transformation
31/12/69 - Acute leukemias of various types are among the most serious blood disorders: leukemia causes severe illness, and the mortality rate is high. A better understanding of the causes of the various forms of leukemia could lead to earlier diagnosis and more effective treatment. The gene ASXL1 is often…

A Phase 3 Trial of l-Glutamine in Sickle Cell Disease
31/12/69 - Oxidative stress contributes to the complex pathophysiology of sickle cell disease. Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous oxidation?reduction (redox) cofactor in red cells. NAD+ and its reduced form, NADH, play major roles in maintaining redox balance. Sickle red cells have a…

l-Glutamine and the Dawn of Combination Therapy for Sickle Cell Disease
31/12/69 - In 2017, the U.S. Food and Drug Administration approved l-glutamine (USAN, glutamine) for the prevention of acute vaso-occlusive pain events in persons with sickle cell disease who are older than 5 years of age ? only the first drug to be approved for this indication in the 20 years since the…

Exploiting Viruses to Treat Diseases
31/12/69 - Viruses have evolved to cause both indolent and explosive disease outbreaks, with millions of people infected with the human immunodeficiency virus and hepatitis viruses and with the current outbreaks of Ebola, yellow fever, and Zika viruses in various parts of the world. As a result of intense…

Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer
31/12/69 - Breast cancer is the most common cancer in women in the United States and worldwide. Hormone-receptor?positive, axillary node?negative disease accounts for approximately half of all cases of breast cancer in the United States. Adjuvant chemotherapy reduces the risk of recurrence, with effects that…

Endocrine Adjuvant Therapy for Localized Breast Cancer
31/12/69 - Investigators now report in the Journal the updated results of two critical trials of endocrine therapy in early-stage breast cancer ? SOFT (Suppression of Ovarian Function Trial) and TEXT (Tamoxifen and Exemestane Trial) ? with overlapping groups that permitted a combined analysis. As in many…

Epigenetic Control of Interleukin-9 in Asthma
31/12/69 - Interleukin-9 is a pleiotropic cytokine associated with allergic inflammation and is a therapeutic target in patients with asthma. Its expression and that of the interleukin-9 receptor are greater in the lungs of persons with asthma than in those of healthy persons. In murine models of allergic…

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