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Nejm News Une Mise à Jour The New England Journal of Medicine by Specialties

 


The New England Journal of Medicine: Search Results in Genetics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Genetics. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

National Coverage Analysis of CAR-T Therapies ? Policy, Evidence, and Payment
31/12/69 - In December 2017, the Boston radio station WBUR chronicled the case of the first patient at Massachusetts General Hospital to receive axicabtagene ciloleucel (Yescarta, Gilead) outside a clinical trial. The chimeric antigen receptor T cells (CAR-Ts) were made from 71-year-old Barbara Kearney?s own…

The Next Phase of Human Gene-Therapy Oversight
31/12/69 - The National Institutes of Health (NIH) and the Food and Drug Administration (FDA) have played key roles in the emergence of safe and effective human gene therapies. Now, we are proposing new efforts to encourage further advances in this rapidly evolving field. The potential to alter human genes…

"Precision" Public Health ? Between Novelty and Hype
31/12/69 - In May 2018, the National Institutes of Health (NIH) began enrollment for a vast medical research cohort. Named "All of Us," it?s meant to include 1 million U.S. volunteers, who will be studied over 10 years at a cost of $1.45 billion. The project promises to "lay the scientific foundation for a…

Classification, Ontology, and Precision Medicine
31/12/69 - A goal of precision medicine is to stratify patients in order to improve diagnosis and medical treatment. Translational investigators are bringing to bear ever greater amounts of heterogeneous clinical data and scientific information to create classification strategies that enable the matching of…

Classification and Personalized Prognosis in Myeloproliferative Neoplasms
31/12/69 - Myeloproliferative neoplasms are clonal hematopoietic disorders comprising polycythemia vera, which is characterized by red-cell overproduction; essential thrombocythemia, which involves elevated platelet counts; and myelofibrosis, which is defined by bone marrow fibrosis. Polycythemia vera and…

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing
31/12/69 - Mycobacterium tuberculosis killed more people than any other pathogen in 2016, a year in which there were estimated to be more than 10 million active cases and 1.7 million patients who died from tuberculosis. In 2014, the World Health Organization (WHO) set a target to "END TB" by 2035,…

The Coming of Age of Drug-Susceptibility Testing for Tuberculosis
31/12/69 - Tuberculosis is the leading infectious cause of death worldwide, claiming 1.6 million lives annually. Antimicrobial resistance is undermining efforts to curb the global tuberculosis epidemic: among the 10.6 million cases of tuberculosis that occurred in 2016, less than a quarter of the estimated…

Bilateral Vestibular Schwannomas in Neurofibromatosis Type 2
31/12/69 - A 32-year-old man presented to the neurosurgery clinic with mild balance difficulties and hearing loss in the left ear. He had a family history of neurofibromatosis type 2 and a diagnosis of tumors in the right and left internal acoustic canals. He had not previously had symptoms related to the…

Neuroblastoma and Histone Demethylation
31/12/69 - Neuroblastoma is a childhood cancer of the sympathetic nervous system, with a propensity for widespread metastasis and aggressive clinical behavior. For patients with so-called high-risk disease (typically patients 18 months of age or older who present with metastatic disease), standard therapy is…

Next-Generation Sequencing to Diagnose Suspected Genetic Disorders
31/12/69 - Clinical next-generation sequencing is being used frequently in medical practices in which genetic testing has traditionally taken place ? for example, medical genetics and medical subspecialties such as neurogenetics. Emerging diagnostic applications include rapid-reporting approaches in intensive…

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