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The New England Journal of Medicine: Search Results in Cardiology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Cardiology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
31/12/69 - Type 2 diabetes mellitus is associated with a substantial risk of cardiovascular and renal disease. The use of inhibitors of sodium?glucose cotransporter 2 (SGLT2) results in favorable effects on biomarkers, including glycemia, blood pressure, weight, intrarenal hemodynamics, and albuminuria, and…

Cognitive Function in a Randomized Trial of Evolocumab
31/12/69 - Statin therapy, ezetimibe, and the proprotein convertase subtilisin?kexin type 9 (PCSK9) inhibitor evolocumab have been shown to reduce the rate of cardiovascular events among patients with established cardiovascular disease. These therapies may result in very low levels of low-density lipoprotein…

Five-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass
31/12/69 - In the 1990s, enthusiasm reemerged for performing coronary-artery bypass grafting (CABG) surgery on a beating heart without the use of cardiopulmonary bypass (off pump). Patients with poor cardiac function or complex coexisting conditions (e.g. lung disease or stroke) initially appeared to have…

Changing the Discussion about On-Pump versus Off-Pump CABG
31/12/69 - The performance of coronary-artery bypass grafting (CABG) without the use of the heart?lung machine (pump) was introduced to avoid the damaging effects of cardiopulmonary bypass. On-pump CABG with cardiopulmonary bypass is generally performed on an arrested heart, and off-pump CABG on a beating…

Nitroprusside and Isoproterenol Use after Major Price Increases
31/12/69 - To the Editor: A number of important pharmaceuticals have undergone dramatic price increases recently. For example, nitroprusside prices have increased by a factor of 30 (wholesale acquisition cost [WAC, the manufacturer?s published catalogue or list price to wholesalers, which may not represent…

Angiotensin II for the Treatment of Vasodilatory Shock
31/12/69 - Shock is a life-threatening syndrome characterized by decreased organ perfusion that can progress to irreversible organ failure. Vasodilatory shock is the most common type of shock and is characterized by peripheral vasodilation and reduced blood pressure despite preserved cardiac output.…

Angiotensin II for the Treatment of Vasodilatory Shock ? Promise and Caution
31/12/69 - Shock is one of the most common reasons for admission of patients to an intensive care unit. Low blood pressure is a hallmark of shock, and raising blood pressure is one of the foremost therapeutic goals in this setting. In patients with vasodilatory (i.e. "distributive") shock, who represent…

Xanthomas in Familial Hypercholesterolemia
31/12/69 - Figure 1.

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
31/12/69 - Angiopoietin-like proteins (ANGPTLs) have been established as important regulators of lipoprotein metabolism and have thus emerged as attractive targets for modulation of lipid levels and cardiovascular disease risk. Loss-of-function variants in ANGPTL4, a negative regulator of lipoprotein lipase…

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides
31/12/69 - Despite advances in the development of lipid-lowering therapies, clinical trials have shown that a substantial risk of cardiovascular disease persists after currently recommended medical therapy. For example, in one trial involving patients who had had an acute coronary syndrome, the lowering of…

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