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The New England Journal of Medicine: Search Results in Cardiology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Cardiology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Uninterrupted Dabigatran versus Warfarin for Ablation in Atrial Fibrillation
31/12/69 - Catheter ablation of atrial fibrillation is a well-established treatment for symptomatic atrial fibrillation. Guidelines have incorporated catheter ablation of symptomatic atrial fibrillation as a class 1 or 2 indication, depending on previous antiarrhythmic treatment and type of atrial…

Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia
31/12/69 - A protein in the lymphocyte antigen 6 (Ly6) superfamily, called GPIHBP1 (glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1), is expressed on the surface of capillary endothelial cells. GPIHBP1 binds lipoprotein lipase in the interstitial spaces (where the lipase is…

Spironolactone Metabolites in TOPCAT ? New Insights into Regional Variation
31/12/69 - To the Editor: In the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, patients with heart failure and preserved ejection fraction were randomly assigned to receive either spironolactone or placebo. The investigators found that the incidence of…

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
31/12/69 - Monoclonal antibodies that inhibit proprotein convertase subtilisin?kexin type 9 (PCSK9) lower levels of plasma low-density lipoprotein (LDL) cholesterol and are promising agents for vascular risk reduction. Patients who have received the fully human monoclonal antibodies evolocumab and alirocumab,…

Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab
31/12/69 - Reducing levels of low-density lipoprotein (LDL) cholesterol with statin therapy is a highly effective method for reducing cardiovascular risk. Trial data, observational studies, and genetic analyses indicate that further reductions in LDL cholesterol levels are likely to confer greater…

Antidrug Antibodies in Patients Treated with Alirocumab
31/12/69 - To the Editor: Immunogenicity led to the discontinuation of clinical development of bococizumab, a murine-derived, humanized antibody to proprotein convertase subtilisin?kexin type 9 (PCSK9), as now described by Ridker et al. in the Journal. Evidence suggests increased immunogenicity potential for…

Diagnosis and Differential Diagnosis of Cushing?s Syndrome
31/12/69 - More than a century ago, Harvey Cushing introduced the term "pluriglandular syndrome" to describe a disorder characterized by rapid development of central obesity, arterial hypertension, proximal muscle weakness, diabetes mellitus, oligomenorrhea, hirsutism, thin skin, and ecchymoses. Cushing knew…

Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes
31/12/69 - Diabetes mellitus is a complex and heterogeneous group of chronic metabolic diseases that are characterized by hyperglycemia. Type 1 diabetes occurs predominantly in young people (diagnosis at 30 years of age or younger) and is generally thought to be precipitated by an immune-associated…

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol
31/12/69 - Low-density lipoprotein (LDL) cholesterol is a causal factor in atherosclerotic cardiovascular disease. Statins have been shown to reduce LDL cholesterol levels and cardiovascular events in large outcome trials, findings that have made them the therapeutic cornerstone of clinical practice. Despite…

Delays in Emergency Care and Mortality during Major U.S. Marathons
31/12/69 - Preparation for large public events frequently involves road closures, an increase in emergency medical services, and interventions to ensure participant safety. In some instances, such as marathons, these changes may have unintended health consequences for nonparticipants. For example, widespread…

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