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The New England Journal of Medicine: Search Results in Cardiology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Cardiology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
31/12/69 - Angiopoietin-like proteins (ANGPTLs) have been established as important regulators of lipoprotein metabolism and have thus emerged as attractive targets for modulation of lipid levels and cardiovascular disease risk. Loss-of-function variants in ANGPTL4, a negative regulator of lipoprotein lipase…

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides
31/12/69 - Despite advances in the development of lipid-lowering therapies, clinical trials have shown that a substantial risk of cardiovascular disease persists after currently recommended medical therapy. For example, in one trial involving patients who had had an acute coronary syndrome, the lowering of…

ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia
31/12/69 - To the Editor: Homozygous familial hypercholesterolemia is characterized by profound genetic deficiencies in the low-density lipoprotein (LDL) receptor pathway; patients with the condition who are not receiving lipid-lowering therapy have LDL cholesterol levels in the range of 500 to 1000 mg per…

Increasing Lipolysis and Reducing Atherosclerosis
31/12/69 - In patients with coronary artery disease, residual cardiovascular risk remains substantial even after levels of low-density lipoprotein (LDL) cholesterol have been effectively lowered by treatment with statins, ezetimibe, or antibodies targeting proprotein convertase subtilisin?kexin type 9…

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
31/12/69 - Aging is associated with an increased incidence of cancer and cardiovascular disease. We and others recently used whole-exome sequencing data to identify a common, age-related disorder marked by an expansion of hematopoietic clones carrying recurrent somatic mutations, most frequently…

Association of Changes in Diet Quality with Total and Cause-Specific Mortality
31/12/69 - Some epidemiologic studies of nutrition focus on dietary patterns rather than single nutrients or foods to evaluate the association between diet and health outcomes. Accumulated evidence supports an association between healthy dietary patterns and a decreased risk of death. Results from recent…

CHIP-ping Away at Atherosclerosis
31/12/69 - Efforts at prevention of cardiovascular disease hinge on the concept of risk factors that, when treated, attenuate the incidence of the disease. Since the concept of cardiovascular risk factors was first proposed in the Framingham Heart Study, many distinct risk algorithms have been developed to…

Mobile Aortic Thrombi
31/12/69 - Figure 1.

Health Effects of Overweight and Obesity in 195 Countries over 25 Years
31/12/69 - The prevalence of overweight and obesity is increasing worldwide. Epidemiologic studies have identified high body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) as a risk factor for an expanding set of chronic diseases, including cardiovascular disease,…

Beating, Fast and Slow
31/12/69 - Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors? commentary follows. Stage. A 52-year-old man presented to his…

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