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The New England Journal of Medicine: Search Results in Allergy\Immunology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Allergy\Immunology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

The Microbiome and Systemic Lupus Erythematosus
31/12/69 - How can it be that such a repugnant substance, feces, is also the key to our well-being? Fecal bacteria are essential to life, and humans are not alone in their dependence on the microbial world. The fruit fly requires acetic acid from Acetobacter pomorum. The bobtail squid needs the luminescence…

Diagnosis and Management of the Antiphospholipid Syndrome
31/12/69 - The antiphospholipid syndrome is a systemic autoimmune disease defined by thrombotic or obstetrical events that occur in patients with persistent antiphospholipid antibodies. Thrombotic antiphospholipid syndrome is characterized by venous, arterial, or microvascular thrombosis. Patients with…

New Biologics for Asthma
31/12/69 - Two articles now published in the Journal indicate that dupilumab, a monoclonal antibody directed against the alpha subunit of the interleukin-4 receptor that inhibits interleukin-4 and interleukin-13 signaling, has a salutary treatment effect in severe asthma. In the first trial, patients with…

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
31/12/69 - Approximately 20% of patients with asthma have uncontrolled, moderate-to-severe disease with recurrent exacerbations and persistent symptoms despite maximized standard-of-care controller therapy. This population is at an increased risk for illness (especially exacerbations) and accounts for…

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma
31/12/69 - An estimated 45% of patients with severe asthma use systemic glucocorticoids to control the disease and prevent exacerbations. However, systemic glucocorticoids act nonselectively and are associated with considerable multiorgan toxic effects and broad immunosuppression. The use of the currently…

On-Demand versus Maintenance Inhaled Treatment in Mild Asthma
31/12/69 - U.S. and international guidelines for the treatment of mild persistent asthma recognize three distinct goals of therapy: to relieve and control symptoms, to prevent exacerbations, and to reduce loss of lung function, with minimal side effects. Short-acting beta-agonists (SABAs), such as albuterol…

Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes
31/12/69 - Familial Mediterranean fever, mevalonate kinase deficiency (also known as the hyperimmunoglobulinemia D syndrome), and the tumor necrosis factor receptor?associated periodic syndrome (TRAPS) are monogenic autoinflammatory diseases that are characterized by recurrent fever episodes, with variable…

Inhaled Combined Budesonide?Formoterol as Needed in Mild Asthma
31/12/69 - Mild asthma, which can be well controlled either with reliever medication (short-acting ?2-agonists [SABAs]) used alone as needed or with low-dose inhaled glucocorticoid or leukotriene-receptor antagonist used as maintenance controller medication, occurs in approximately 50 to 75% of patients with…

As-Needed Budesonide?Formoterol versus Maintenance Budesonide in Mild Asthma
31/12/69 - Mild asthma often remains poorly controlled despite the availability of effective treatments. Current guidelines recommend that most patients with mild asthma be treated with regular, low-dose inhaled glucocorticoids as controller medication to reduce the risk of exacerbations, with short-acting…

Relapsing Polychondritis
31/12/69 - A 31-year-old man presented to the emergency department with a 2-week history of swelling of the left ear and a 6-month history of weight loss, fatigue, and generalized aches. During the 2 years before presentation, he had been treated multiple times with antibiotics for recurrent episodes of pain…

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