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The New England Journal of Medicine: Search Results in Allergy\Immunology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Allergy\Immunology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Salt-and-Pepper Skin Changes
31/12/69 - Figure 1.

Beating, Fast and Slow
31/12/69 - Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors? commentary follows. Stage. A 52-year-old man presented to his…

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis
31/12/69 - Genetic inquiry has contributed to our understanding of gastrointestinal diseases, associating at least 64 genes with early-onset or very-early-onset inflammatory bowel disease. Deleterious gene variants affect the intestinal epithelial barrier, phagocytosis processes, immune regulation, and…

Unmasking Ptosis in Both Eyes
31/12/69 - Figure 1.

Loss of CD55 in Eculizumab-Responsive Protein-Losing Enteropathy
31/12/69 - To the Editor: Protein-losing enteropathy usually manifests as peripheral and visceral edema due to hypoalbuminemia. We followed a large consanguineous Muslim?Arab family that included six patients who had protein-losing enteropathy associated with hypercoagulability (Fig. S1A in the Supplementary…

Oral Glucocorticoid?Sparing Effect of Benralizumab in Severe Asthma
31/12/69 - Asthma is a common chronic inflammatory disease of the airways that affects an estimated 315 million persons worldwide. Approximately 5 to 10% of persons with asthma have a severe form of disease that is usually managed with high-dose inhaled glucocorticoids and bronchodilators. Within this group,…

Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis
31/12/69 - Eosinophilic granulomatosis with polyangiitis (formerly known as the Churg?Strauss syndrome) is characterized by asthma, sinusitis, pulmonary infiltrates, neuropathy, and eosinophilic vasculitis of one or more end-organs. Eosinophils are thought to induce pathogenic effects in patients with…

KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma
31/12/69 - Many patients with severe asthma do not have adequate disease control despite the use of high-dose inhaled or systemic glucocorticoids. Severe asthma is associated with airway hyperresponsiveness ? that is, an exaggerated response to a bronchoconstrictor stimulus ? and airway inflammation, both of…

Reversal of Autoimmune Toxicity and Loss of Tumor Response by Interleukin-17 Blockade
31/12/69 - To the Editor: Patients with autoimmune diseases have typically been excluded from immunotherapy clinical trials, although recent evidence suggests that the benefits of checkpoint therapy may outweigh the risks of autoimmune flare-ups in carefully selected patients who have a high probability of…

Mast Cells and KIT as Potential Therapeutic Targets in Severe Asthma
31/12/69 - Mast cells and many of their secreted products have long been thought to contribute to the pathologic processes underlying asthma, but no clinical studies have assessed whether specifically targeting mast-cell survival or development would have therapeutic benefit in the treatment of this disorder.…

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