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The New England Journal of Medicine: Search Results in Allergy\Immunology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Allergy\Immunology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1
31/12/69 - LAD1 is a primary immunodeficiency resulting from mutations in ITGB2, which encodes the common CD18 subunit of the ?2 integrins; the ?2 integrins are required for the adhesion of neutrophils to endothelium and the transmigration of neutrophils into tissues. Patients with LAD1 typically have…

Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor
31/12/69 - Hereditary angioedema is a disabling and potentially fatal condition characterized by recurrent episodes of swelling without urticaria or pruritus. The condition is caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein. Patients have insufficient C1 inhibitor function…

ST2 and Endothelial Injury as a Link between GVHD and Microangiopathy
31/12/69 - To the Editor: Vander Lugt et al. (Aug. 8, 2013, issue) report an association between elevated levels of ST2 protein, a marker of endothelial injury, at the time of diagnosis of graft-versus-host disease (GVHD) and resistance to glucocorticoid therapy among the recipients of hematopoietic stem-cell…

Breaking a Vicious Cycle
31/12/69 - In this issue of the Journal, Moutsopoulos et al. report on a patient with leukocyte adhesion deficiency type 1 (LAD1) who was successfully treated with ustekinumab, a monoclonal antibody to the p40 subunit common to interleukin-12 and interleukin-23. Patients with LAD1 have defective neutrophil…

Post-Babesiosis Warm Autoimmune Hemolytic Anemia
31/12/69 - Babesiosis is a tickborne zoonotic disease that is caused by intraerythrocytic protozoa of the genus babesia. In the northeastern and upper midwestern regions of the United States, where Babesia microti is endemic, the incidence of babesiosis has increased dramatically in the past 10 years,…

Histology Rings True
31/12/69 - Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors? commentary follows. Stage. A 58-year-old man with nonerosive…

Anti?Interleukin-31 Receptor A Antibody for Atopic Dermatitis
31/12/69 - Atopic dermatitis is a chronic pruritic, inflammatory skin disease that is triggered by an immune response to antigenic substances, irritants, and mechanical irritation and which is often associated with a personal or family history of type 1 allergies, allergic rhinitis, or asthma. Pruritus often…

Ditching the Itch with Anti?Type 2 Cytokine Therapies for Atopic Dermatitis
31/12/69 - Atopic dermatitis is a chronic inflammatory disease characterized by intense pruritus and dry, inflamed skin. An impaired skin barrier and a dysregulated immune response to a variety of triggers are key factors in the complex pathophysiological mechanism of this disease. The predominant early…

Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis
31/12/69 - Hereditary angioedema with C1 inhibitor deficiency is a rare genetic disease that is characterized by recurrent swelling episodes, typically affecting the subcutaneous or submucosal tissues of the hands and feet, abdomen, face, larynx, or genitourinary tract. Swelling of the larynx can be…

Kallikrein Inhibition for Hereditary Angioedema
31/12/69 - Management of hereditary angioedema due to C1 inhibitor deficiency has evolved. During the past 10 years, those affected have progressed from underrecognized disability and premature death, through evidence-based hospital treatment, toward self-administration and independence from unscheduled…

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