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The New England Journal of Medicine: Search Results in Allergy\Immunology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Allergy\Immunology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema
31/12/69 - Hereditary angioedema is a genetic disorder characterized by recurrent episodes of swelling. Oropharyngeal swelling can be life-threatening, and attacks in other sites, including the limbs, genitalia, face, and intestines, can be painful, disabling, and disfiguring and have a substantial effect on…

Epigenetic Control of Interleukin-9 in Asthma
31/12/69 - Interleukin-9 is a pleiotropic cytokine associated with allergic inflammation and is a therapeutic target in patients with asthma. Its expression and that of the interleukin-9 receptor are greater in the lungs of persons with asthma than in those of healthy persons. In murine models of allergic…

Combined Analysis of Asthma Safety Trials of Long-Acting ?2-Agonists
31/12/69 - Because of concerns about the safety of long-acting ?2-agonists (LABAs) in asthma management, the Food and Drug Administration (FDA) in 2010 issued a public health advisory stating that LABAs should not be used as first-line therapy for asthma, and a boxed warning was required for all products…

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma
31/12/69 - An estimated 45% of patients with severe asthma use systemic glucocorticoids to control the disease and prevent exacerbations. However, systemic glucocorticoids act nonselectively and are associated with considerable multiorgan toxic effects and broad immunosuppression. The use of the currently…

New Biologics for Asthma
31/12/69 - Two articles now published in the Journal indicate that dupilumab, a monoclonal antibody directed against the alpha subunit of the interleukin-4 receptor that inhibits interleukin-4 and interleukin-13 signaling, has a salutary treatment effect in severe asthma. In the first trial, patients with…

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
31/12/69 - Approximately 20% of patients with asthma have uncontrolled, moderate-to-severe disease with recurrent exacerbations and persistent symptoms despite maximized standard-of-care controller therapy. This population is at an increased risk for illness (especially exacerbations) and accounts for…

Inhaled Corticosteroids and LABAs ? Removal of the FDA?s Boxed Warning
31/12/69 - For years, the risks associated with the use of long-acting beta-agonists (LABAs) in patients with asthma have been uncertain, and some health care professionals have recommended conducting large clinical trials to gather important safety information on these products. In December 2017, the Food…

The Microbiome and Systemic Lupus Erythematosus
31/12/69 - How can it be that such a repugnant substance, feces, is also the key to our well-being? Fecal bacteria are essential to life, and humans are not alone in their dependence on the microbial world. The fruit fly requires acetic acid from Acetobacter pomorum. The bobtail squid needs the luminescence…

Diagnosis and Management of the Antiphospholipid Syndrome
31/12/69 - The antiphospholipid syndrome is a systemic autoimmune disease defined by thrombotic or obstetrical events that occur in patients with persistent antiphospholipid antibodies. Thrombotic antiphospholipid syndrome is characterized by venous, arterial, or microvascular thrombosis. Patients with…

Inhaled Combined Budesonide?Formoterol as Needed in Mild Asthma
31/12/69 - Mild asthma, which can be well controlled either with reliever medication (short-acting ?2-agonists [SABAs]) used alone as needed or with low-dose inhaled glucocorticoid or leukotriene-receptor antagonist used as maintenance controller medication, occurs in approximately 50 to 75% of patients with…

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