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The New England Journal of Medicine: Search Results in Allergy\Immunology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Allergy\Immunology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Antibody-Mediated Rejection of Solid-Organ Allografts
31/12/69 - End-stage organ diseases are responsible for millions of deaths worldwide each year. Organ transplantation has become the treatment of choice, but despite the 120,000 new organ transplantations performed each year, only 1 million persons worldwide have functioning solid-organ transplants because of…

Case 27-2018: A 3-Year-Old Boy with Seizures
31/12/69 - Presentation Of Case. Dr. Caitlin E. Naureckas Li (Pediatrics): A 3-year-old boy was admitted to this hospital during the summer because of a seizure. The patient had been well until 3 days before admission, when one episode of emesis occurred. The following evening, he was fussy, and on the third…

Lichen Planus
31/12/69 - A 69-year-old man presented to the dermatology clinic with a 2-month history of a pruritic rash. The rash had first appeared on his right wrist and within 2 weeks had spread to his arms, legs, and trunk. His medical history was notable for chronic hepatitis C virus (HCV) infection, for which he had…

Case 24-2018: A 71-Year-Old Man with Acute Renal Failure and Hematuria
31/12/69 - Presentation of Case. Dr. Joshua Z. Drago (Medicine): A 71-year-old man was transferred to this hospital because of worsening renal function and hematuria. Three weeks before this admission, the patient?s wife became ill with chills, fatigue, and myalgias, and she thought she had influenza. A few…

Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema
31/12/69 - Hereditary angioedema is a genetic disorder characterized by recurrent episodes of swelling. Oropharyngeal swelling can be life-threatening, and attacks in other sites, including the limbs, genitalia, face, and intestines, can be painful, disabling, and disfiguring and have a substantial effect on…

Epigenetic Control of Interleukin-9 in Asthma
31/12/69 - Interleukin-9 is a pleiotropic cytokine associated with allergic inflammation and is a therapeutic target in patients with asthma. Its expression and that of the interleukin-9 receptor are greater in the lungs of persons with asthma than in those of healthy persons. In murine models of allergic…

Combined Analysis of Asthma Safety Trials of Long-Acting ?2-Agonists
31/12/69 - Because of concerns about the safety of long-acting ?2-agonists (LABAs) in asthma management, the Food and Drug Administration (FDA) in 2010 issued a public health advisory stating that LABAs should not be used as first-line therapy for asthma, and a boxed warning was required for all products…

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma
31/12/69 - An estimated 45% of patients with severe asthma use systemic glucocorticoids to control the disease and prevent exacerbations. However, systemic glucocorticoids act nonselectively and are associated with considerable multiorgan toxic effects and broad immunosuppression. The use of the currently…

New Biologics for Asthma
31/12/69 - Two articles now published in the Journal indicate that dupilumab, a monoclonal antibody directed against the alpha subunit of the interleukin-4 receptor that inhibits interleukin-4 and interleukin-13 signaling, has a salutary treatment effect in severe asthma. In the first trial, patients with…

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
31/12/69 - Approximately 20% of patients with asthma have uncontrolled, moderate-to-severe disease with recurrent exacerbations and persistent symptoms despite maximized standard-of-care controller therapy. This population is at an increased risk for illness (especially exacerbations) and accounts for…

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