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The New England Journal of Medicine: Search Results in Hematology\Oncology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Hematology\Oncology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer
31/12/69 - Antibodies that block the immune inhibitory pathway of programmed death 1 (PD-1) protein have provided a major treatment advance in patients with cancer. In some patients with advanced non?small-cell lung cancer (NSCLC), these drugs unleash antitumor immunity, resulting in tumor regression and…

Raindrop Skull
31/12/69 - A 46-year-old man presented to the emergency department with a 1-month history of fatigue, shortness of breath, and low back pain and report of a weight loss of 30 kg over the previous 10 months. On physical examination, his conjunctiva and palms were pale. Laboratory evaluation revealed a…

Rapid Progression of Adult T-Cell Leukemia?Lymphoma after PD-1 Inhibitor Therapy
31/12/69 - To the Editor: Adult T-cell leukemia?lymphoma (ATLL) is an aggressive clonal T-cell cancer caused by human T-cell leukemia virus type 1 (HTLV-1). Responses to interferon, zidovudine, arsenic, or mogamulizumab are generally short-lived. Genomic analysis has shown a higher mutation rate in ATLL than…

Trametinib in Histiocytic Sarcoma with an Activating MAP2K1 (MEK1) Mutation
31/12/69 - To the Editor: A high prevalence of BRAF V600E mutations are detected in patients with Langerhans?-cell histiocytosis and Erdheim?Chester disease, which is a subset of non?Langerhans?-cell histiocytosis. Vemurafenib, a BRAF inhibitor, has shown sustained efficacy in patients with Langerhans?-cell…

Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma
31/12/69 - The development of effective adjuvant therapies for patients with high-risk melanoma has been preceded by the recent arrival of active agents to treat metastatic melanoma, including ipilimumab (an anti-CTLA4 antibody), pembrolizumab and nivolumab (both monoclonal antibodies against programmed death…

MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis
31/12/69 - Men with a clinical suspicion of prostate cancer on the basis of an elevated prostate-specific antigen (PSA) level or an abnormal digital rectal examination are typically offered a standard transrectal ultrasonography?guided biopsy of the prostate during which 10 to 12 cores are obtained. This…

Investigational Testing for Zika Virus among U.S. Blood Donors
31/12/69 - Zika virus (ZIKV), an arthropod-borne virus (arbovirus) of the genus flavivirus, was identified in a sentinel rhesus monkey in the Zika Forest of Uganda in 1947 and was isolated from mosquitoes (Aedes africanus) in 1948. Outbreaks of ZIKV infection were observed in Yap Island, Federated States of…

Intravenous Immune Globulin to Prevent Heparin-Induced Thrombocytopenia
31/12/69 - To The Editor: Heparin-induced thrombocytopenia is a prothrombotic drug reaction caused by anti?platelet factor 4 (PF4)?heparin antibodies of the IgG class that activate platelets through platelet Fc? receptors. Although treatment with nonheparin anticoagulation is emphasized, recent attention has…

Tackling Tumors with Small RNAs Derived from Transfer RNA
31/12/69 - Only approximately 1% of the human genome is made up of genes that encode proteins. Our understanding of the rest of our genome is scant: it is ? for the most part ? a world undiscovered. (It is also true that the function of many genes is not understood, even though this minuscule portion of the…

Maternal Sirolimus Therapy for Fetal Cardiac Rhabdomyomas
31/12/69 - To the Editor: Cardiac rhabdomyoma is the most common fetal cardiac tumor. We report a case of progressively obstructive fetal cardiac rhabdomyomas with regression in utero during treatment of the mother with an oral mechanistic target of rapamycin (mTOR) inhibitor. Cardiac rhabdomyomas were…

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