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The New England Journal of Medicine: Search Results in Hematology\Oncology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Hematology\Oncology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Just Beneath the Surface
31/12/69 - In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors? commentary follows. A 55-year-old man was evaluated in…

Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma
31/12/69 - Rituximab plus chemotherapy followed by maintenance therapy with rituximab has been shown to be effective in patients with advanced follicular lymphoma for whom treatment is indicated, with median progression-free survival reaching approximately 6 to 10 years and with a 3-year overall survival rate…

Circulating Extracellular Vesicles in Human Disease
31/12/69 - It is well known that cells release fluid-filled sacs (vesicles) to the extracellular environment during cell death, or apoptosis, but it has been increasingly recognized that healthy cells may also release vesicles in the process of normal functions. Vesicles that are released by healthy cells…

High-Risk Clonal Hematopoiesis as the Origin of AITL and NPM1-Mutated AML
31/12/69 - To the Editor: Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of hematologic neoplasms. CHIP is most common in older patients, who usually carry a single somatic mutation (which provides a fitness advantage) in a minority of hematopoietic cells. Here, we…

Life Lessons from Paul in the Face of Death
31/12/69 - My brother Paul, a rabbi, died recently, just shy of 3 years after the diagnosis of widely metastatic colon cancer. The story of his diagnosis and treatment is all too familiar. An apparently healthy 64-year-old man has a sudden onset of lower abdominal pain. Imaging reveals an obstructing lesion.…

Bile Acids, the Microbiome, Immunity, and Liver Tumors
31/12/69 - Hepatocellular carcinoma is among the leading causes of tumor-related death, and the liver is among the most common sites of cancer metastasis. Several types of immune cells surveil the liver to detect and kill premalignant and malignant cells and to prevent the development of cancer. At the…

Koilonychia in Iron-Deficiency Anemia
31/12/69 - A 54-year-old woman presented to the primary care clinic with fatigue and a 7-year history of intermittent hemorrhoidal bleeding. On examination, she appeared pale and had spoon-shaped nails (koilonychia) on the second and third fingers (Panel A) and the thumb (Panel B) of both hands. The…

Emicizumab Prophylaxis in Patients Who Have Hemophilia A without Inhibitors
31/12/69 - Regular prophylactic intravenous infusion of factor VIII is the current treatment for persons with severe hemophilia A. However, because of the half-life of factor VIII, more than two infusions per week are necessary for maintaining protective trough levels, which results in a substantial treatment…

Mimicking Factor VIII to Manage the Factor VIII?Deficient State
31/12/69 - Hemophilia A is an X-linked disorder caused by defective factor VIII, which until now has involved factor VIII replacement to treat and prevent bleeding in joints, muscles, and other body cavities. Although factor VIII replacement is effective, the treatment burden is high, because intravenous…

Langerhans-Cell Histiocytosis
31/12/69 - Langerhans-cell histiocytosis (LCH), the most common histiocytic disorder, encompasses conditions characterized by aberrant function and differentiation or proliferation of cells of the mononuclear phagocyte system. "Histiocyte" is an archaic term (meaning "tissue cell") used to describe phagocytic…

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