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Nejm News Une Mise à Jour The New England Journal of Medicine by Specialties

 


The New England Journal of Medicine: Search Results in Hematology\Oncology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Hematology\Oncology. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa
31/12/69 - Sickle hemoglobinopathies are common and life-threatening genetic disorders. Homozygous hemoglobin S (HbSS) is the most severe genotype, and together with hemoglobin S?0 thalassemia, is called sickle cell anemia. On deoxygenation, erythrocytes become sickle-shaped, rigid, adhesive, and prone to…

Hydroxyurea ? An Essential Medicine for Sickle Cell Disease in Africa
31/12/69 - Higher levels of fetal hemoglobin (HbF) ameliorate the clinical course of sickle cell disease. Hydroxyurea, an inhibitor of the enzyme ribonucleoside diphosphate reductase, increases HbF synthesis by erythroid cells (Figure 1). More than 20 years ago, a major clinical trial of hydroxyurea in the…

Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer
31/12/69 - Esophageal cancer is among the cancers with the most rapidly increasing incidence in the Western world. Overall survival among patients with esophageal cancer remains poor; the 5-year survival is 10 to 15% among all patients but increases to 40% among patients who undergo curative surgery.…

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura
31/12/69 - Acquired or immune-mediated thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy that is characterized by thrombocytopenia and hemolytic anemia. Autoantibodies inhibit activity of the von Willebrand factor?cleaving protease ADAMTS13 (a disintegrin and metalloproteinase…

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease
31/12/69 - Long prescribed to prevent and treat bone-related disorders, supplemental vitamin D has been viewed in recent years as a potential strategy for preventing cancer and cardiovascular disease. In the United States, routine assessment of vitamin D status in patients in primary care settings and the use…

A Breath-Taking Diagnosis
31/12/69 - Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors? commentary follows. Stage. A 71-year-old woman…

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma
31/12/69 - Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin?s lymphoma. Although in the majority of patients the condition responds well to first-line immunochemotherapy combinations containing rituximab, 10 to 15% have primary refractory disease within 3 months after treatment initiation,…

Marine n?3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
31/12/69 - Marine-derived long-chain n?3 (also called omega-3) fatty acids have shown promise for the primary prevention of cardiovascular disease in studies in animals; in small, randomized trials designed with intermediate cardiovascular end points; and in observational epidemiologic investigations.…

Addressing a Core Gap in Cancer Care ? The NCI Moonshot Program to Help Oncology Patients Stop Smoking
31/12/69 - Despite making great progress in caring for people with cancer, the oncology community has often neglected to capitalize on a highly feasible, readily available, and cost-effective strategy for increasing the success of cancer treatment and rates of recovery ? smoking cessation. Effective…

Progress in BRCA-Mutated Ovarian Cancer
31/12/69 - The article by Moore et al. in this issue of the Journal is the culmination of a long march for olaparib in the treatment of BRCA-mutated high-grade serous ovarian cancer ? one that began with its discovery by means of synthetic lethality screening, followed by years of clinical trials to define…

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