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The New England Journal of Medicine: Search Results in Pediatrics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pediatrics. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Neural-Tube Defects with Dolutegravir Treatment from the Time of Conception
31/12/69 - To the Editor: Since August 2014, the Botswana Harvard AIDS Institute Partnership has conducted birth outcome surveillance at eight government hospitals throughout Botswana. A primary ongoing aim of the surveillance is to evaluate the prevalence of neural-tube defects associated with exposure to…

Protecting Mothers and Babies ? A Delicate Balancing Act
31/12/69 - More than 50 years ago, an epidemic of serious birth defects caused by prenatal exposure to thalidomide shattered the prevailing notion that the placenta served as a barrier against damaging influences and led to recognition that exposures during pregnancy can result in harm to a developing fetus.…

A Step Forward in the Treatment of Influenza
31/12/69 - For many years, antiviral treatment of influenza has consisted of monotherapy with a neuraminidase inhibitor. The Food and Drug Administration (FDA) approved the neuraminidase inhibitors oseltamivir (oral administration) and zanamivir (oral inhalation) in 1999 and peramivir (intravenous…

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents
31/12/69 - Additional effective antiviral agents are needed for the treatment and prevention of influenza virus infections. Two classes of agents, M2 ion-channel inhibitors and neuraminidase inhibitors, are widely available. However, circulating influenza viruses are now largely resistant to M2 ion-channel…

Bitot?s Spots
31/12/69 - A 4-year-old boy was brought by his father to the ophthalmology clinic with a 1-year history of enlarging white deposits in both eyes and decreased night vision. On examination, the conjunctivae of both the right eye (Panel A) and the left eye (Panel B) appeared dry and wrinkled, with foamy,…

Emicizumab Prophylaxis in Patients Who Have Hemophilia A without Inhibitors
31/12/69 - Regular prophylactic intravenous infusion of factor VIII is the current treatment for persons with severe hemophilia A. However, because of the half-life of factor VIII, more than two infusions per week are necessary for maintaining protective trough levels, which results in a substantial treatment…

Epilepsy Profile in Infants with Congenital Zika Virus Infection
31/12/69 - To the Editor: Congenital Zika virus (ZIKV) infection may have severe clinical consequences, including dysmorphic features, orthopedic abnormalities, ophthalmologic and auditory lesions, microcephaly, and hydrocephalus. When ZIKV infection is acquired in utero, it may be associated with epilepsy,…

Case 27-2018: A 3-Year-Old Boy with Seizures
31/12/69 - Presentation Of Case. Dr. Caitlin E. Naureckas Li (Pediatrics): A 3-year-old boy was admitted to this hospital during the summer because of a seizure. The patient had been well until 3 days before admission, when one episode of emesis occurred. The following evening, he was fussy, and on the third…

Mimicking Factor VIII to Manage the Factor VIII?Deficient State
31/12/69 - Hemophilia A is an X-linked disorder caused by defective factor VIII, which until now has involved factor VIII replacement to treat and prevent bleeding in joints, muscles, and other body cavities. Although factor VIII replacement is effective, the treatment burden is high, because intravenous…

Langerhans-Cell Histiocytosis
31/12/69 - Langerhans-cell histiocytosis (LCH), the most common histiocytic disorder, encompasses conditions characterized by aberrant function and differentiation or proliferation of cells of the mononuclear phagocyte system. "Histiocyte" is an archaic term (meaning "tissue cell") used to describe phagocytic…

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