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The New England Journal of Medicine: Search Results in Pediatrics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pediatrics. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy
31/12/69 - Juvenile myoclonic epilepsy is the most common form of genetic generalized epilepsy and the most common cause of seizures among adolescents and young adults. The disorder is distinguished by the clinical features of myoclonus when the patient awakens from sleep after being sleep-deprived or exposed…

Osgood?Schlatter Disease
31/12/69 - A 13-year-old boy presented to the orthopedic clinic with a 1-week history of pain in both knees. He was active in sports and had participated in the long jump during the previous 6 months. He reported no specific trauma, fever, or other joint symptoms. A physical examination of the right knee…

Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations
31/12/69 - Asthma exacerbations are common events, particularly in school-age children. Exacerbations are costly and are associated with considerable complications. In addition, asthma exacerbations may lead to progressive loss of lung function and greater asthma severity over time. Although conventional…

Tenofovir versus Placebo to Prevent Perinatal Transmission of Hepatitis B
31/12/69 - Mother-to-child transmission of hepatitis B virus (HBV) accounts for the majority of cases of chronic HBV infection, a leading cause of cirrhosis and hepatocellular carcinoma worldwide. Without immunization, 30 to 42% of the infants born to HBV-infected mothers, depending on the maternal status for…

Escalating Inhaled Glucocorticoids to Prevent Asthma Exacerbations
31/12/69 - Inhaled glucocorticoids are pivotal to achieve asthma control and disease stability in both children and adults; despite their use, with or without other treatments, many patients with asthma have ongoing episodic disease exacerbations. Often, these are linked to provocative factors such as viral…

Where There?s Wildfire, There?s Smoke
31/12/69 - With the undeniable march of climate change, the danger of catastrophic wildfires is increasing around the globe, with such fires occurring in Australia, Canada, Chile, Indonesia, Portugal, and Russia, as well as the United States, over the past decade. Large forest fires in the western United…

A Shift in Thinking to Reduce Mother-to-Infant Transmission of Hepatitis B
31/12/69 - The morbidity and mortality that are associated with hepatitis B virus (HBV) infection have been overshadowed by the public health prominence of other infectious diseases, including human immunodeficiency virus (HIV) infection, tuberculosis, and malaria. There is a dawning realization that the…

Efficacy of Larotrectinib in TRK Fusion?Positive Cancers in Adults and Children
31/12/69 - The neurotrophic receptor tyrosine kinase genes NTRK1, NTRK2, and NTRK3 encode the tropomyosin receptor kinase (TRK) proteins TRKA, TRKB, and TRKC, respectively. After embryogenesis, TRK expression is limited primarily to the nervous system, where these kinases help regulate pain, proprioception,…

Human Neonatal Rotavirus Vaccine (RV3-BB) to Target Rotavirus from Birth
31/12/69 - Despite evidence of the success of rotavirus vaccines, more than 90 million infants still lack access to a rotavirus vaccine. Barriers to global implementation of the vaccine include cost, suboptimal efficacy in low-income countries, and lingering safety concerns. An oral rotavirus vaccine…

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy
31/12/69 - Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder that is characterized by atrophy and weakness of the skeletal muscles of the limbs and trunk and of the bulbar and respiratory muscles. It is caused by homozygous deletions or loss-of-function mutations in the gene…

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