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Nejm News Une Mise à Jour The New England Journal of Medicine by Specialties

 


The New England Journal of Medicine: Search Results in Pediatrics
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pediatrics. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Hemoglobinopathies in the Fetal Position
31/12/69 - The hemoglobinopathies, disorders that are caused by mutations in genes that encode the "adult" globins, exert a devastating toll on patients and their families. Worldwide, approximately 300,000 babies are born with sickle cell disease and 60,000 are born with ?-thalassemia each year. However, if…

Triple CFTR Modulator Therapy for Cystic Fibrosis
31/12/69 - Cystic fibrosis is one of the most common life-threatening autosomal recessive disorders, affecting approximately 80,000 children and adults worldwide. It is caused by mutations that result in deficient or defective function of the cystic fibrosis transmembrane conductance regulator (CFTR), an…

VX-659?Tezacaftor?Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
31/12/69 - Cystic fibrosis is a serious, autosomal-recessive, multisystem disease that affects approximately 80,000 people worldwide and is associated with early death due to progressive lung disease. Cystic fibrosis is caused by diminished quantity and defective function of an epithelial anion channel, the…

VX-445?Tezacaftor?Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
31/12/69 - Cystic fibrosis is a rare, progressive, lethal, recessive genetic disease caused by diminished quantity or function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, an epithelial channel that conducts chloride and other anions, as a consequence of mutations in CFTR. In a…

Neuroblastoma and Histone Demethylation
31/12/69 - Neuroblastoma is a childhood cancer of the sympathetic nervous system, with a propensity for widespread metastasis and aggressive clinical behavior. For patients with so-called high-risk disease (typically patients 18 months of age or older who present with metastatic disease), standard therapy is…

Acne Vulgaris
31/12/69 - Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author?s clinical recommendations. Stage. A 15-year-old…

Determinants of Risk for Childhood Obesity
31/12/69 - The body-fat content of a healthy full-term infant rises sharply from 10 to 14% at birth to 25 to 30% at 6 months of age, with a consequent 30% increase in the body-mass index (BMI). The accrual of body fat during infancy correlates with, and may be required for, normal linear growth, brain…

Acceleration of BMI in Early Childhood and Risk of Sustained Obesity
31/12/69 - The overall prevalence of childhood obesity remains very high, and the prevalence of very high levels of body-mass index (BMI) for age in children is still rising. Most adolescents who are obese remain so in adulthood. The early onset of obesity is associated with the emergence of related…

Case 29-2018: A 31-Year-Old Woman with Infertility
31/12/69 - Presentation of Case. Dr. Caitlin Sacha (Obstetrics and Gynecology): A 31-year-old woman with infertility was referred to the fertility center of this hospital by a surrogate parenting agency to discuss the possibility of family building with an oocyte donor and a gestational carrier. The patient…

Variation in Childhood Diarrheal Morbidity and Mortality in Africa, 2000?2015
31/12/69 - Diarrhea-related deaths in children are largely preventable. Unfortunately, the burden of diarrhea remains high and inadequately characterized owing to the complex interplay that the environment, food, water, and sanitation have with poverty and deprivation. A considerable proportion of cases of…

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