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The New England Journal of Medicine: Search Results in Nephrology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Nephrology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Diagnostic Utility of Exome Sequencing for Kidney Disease
31/12/69 - Targeted capture and sequencing of the protein-coding regions of the genome through exome sequencing is increasingly applied as a first-line diagnostic tool in clinical medicine, particularly for the diagnosis of metabolic and neurodevelopmental disorders in children, as well as for the detection…

Worldwide Frequencies of APOL1 Renal Risk Variants
31/12/69 - To the Editor: Risk variants in the APOL1 gene on chromosome 22, which were first discovered in African Americans, confer a substantially increased risk of kidney disease, early-onset hypertension, and cardiovascular disease, although disease risk is modified by other genetic factors and by…

Factor H Autoantibodies and Membranous Nephropathy
31/12/69 - To the Editor: Approximately 80% of patients with primary membranous nephropathy have phospholipase A2 receptor (PLA2R) antibodies, predominantly of the IgG4 subclass. C3 and C5b-9 occur in glomerular immune deposits, which implicates complement activation as a putative effector mechanism. In…

Tackling Tsc1 to Promote Nephrogenesis
31/12/69 - The mammalian kidney, in addition to filtering and removing waste from the blood (and thereby producing urine), regulates blood pressure, bodily fluids, and salts and minerals and produces hormones that regulate erythropoiesis and other processes. Metanephric kidney development is completed late in…

Case 36-2018: A 29-Year-Old Man with an Incidentally Discovered Renal Mass
31/12/69 - Presentation of Case. Dr. Keyan Salari (Urology): A 29-year-old man was seen at this hospital because of an incidentally discovered renal mass. The patient had been well until 6 weeks before this evaluation, when he identified a painless lump above his left testicle during a monthly…

Take It with a Grain of Salt
31/12/69 - A 56-year-old woman presented to the emergency department with a 1-week history of frontotemporal headaches and nausea. She also noted mild upper respiratory symptoms and cough, which she had treated with codeine. When her headaches had progressed to what she described as "the worst pain in her…

Complements from the Lung
31/12/69 - Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors? commentary follows. Stage. A 26-year-old man…

Intravenous Iron in Patients Undergoing Maintenance Hemodialysis
31/12/69 - Patients undergoing maintenance hemodialysis usually have a negative iron balance owing to reduced absorption and increased blood loss. The intravenous administration of iron has become standard care in the management of anemia, and large doses are increasingly used to reduce exposure to…

Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis
31/12/69 - Acute kidney injury is a frequent complication in patients hospitalized in the intensive care unit (ICU) for septic shock and is associated with high mortality. Acute kidney injury associated with sepsis is characterized by a distinct pathophysiology, and patients with acute kidney injury and…

Fatal Encephalitic Borna Disease Virus 1 in Solid-Organ Transplant Recipients
31/12/69 - To the Editor: Borna disease virus 1 (BoDV-1; species Mammalian 1 orthobornavirus) causes progressive meningoencephalitis, mainly in horses and sheep. Evidence of BoDV-1 infection in humans is limited. However, after the identification of a bornavirus transmitted by exotic pet squirrels ? the…

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