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The New England Journal of Medicine: Search Results in Nephrology
The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Nephrology. NEJM ( is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

Uremic Frost in End-Stage Renal Disease
31/12/69 - A 39-year-old man with end-stage renal disease presented to the emergency department with anorexia, nausea, vomiting, and oliguria. Five months earlier, he had stopped attending his regular hemodialysis sessions; he reported that he had thought that the sessions were not needed because he continued…

Case 24-2018: A 71-Year-Old Man with Acute Renal Failure and Hematuria
31/12/69 - Presentation of Case. Dr. Joshua Z. Drago (Medicine): A 71-year-old man was transferred to this hospital because of worsening renal function and hematuria. Three weeks before this admission, the patient?s wife became ill with chills, fatigue, and myalgias, and she thought she had influenza. A few…

Cytoreductive Nephrectomy ? Patient Selection Is Key
31/12/69 - Metastatic renal-cell carcinoma has diverse clinical presentations ranging from incidental detection to a highly symptomatic systemic illness. Patients with metastatic renal-cell carcinoma are assigned a risk category ? favorable, intermediate, or poor ? on the basis of two published models…

Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma
31/12/69 - Kidney cancer accounts for 5% of all cancers in men and 3% of all cancers in women, and approximately 15% of these are metastatic at diagnosis. More than 15 years ago, randomized, controlled trials showed prolonged survival with initial nephrectomy, as compared with immunotherapy alone, among…

A Reliable Diagnostic Test for Hypotonic Polyuria
31/12/69 - Pinpointing the cause of hypotonic polyuria in a patient poses a diagnostic and therapeutic challenge, particularly in distinguishing primary polydipsia (either psychogenic or nonpsychogenic) from partial pituitary insufficiency due to injury or neoplasm. Diabetes insipidus is one cause of…

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus
31/12/69 - The determination of a specific diagnosis in patients with polyuria and low plasma osmolality (i.e. hypotonic polyuria) is a frequent problem in clinical practice. In the absence of osmotic diuresis, polyuria can result from one of three fundamentally different conditions: insufficient production…

Case 19-2018: A 15-Year-Old Girl with Acute Kidney Injury
31/12/69 - Presentation of Case. Dr. Helen I. Healy (Pediatrics): A 15-year-old girl was admitted to this hospital during the summer because of acute kidney injury. The patient had been well until 8 days before admission, when painful cramping in the lower abdomen and bloody diarrhea developed. Bowel…

Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery
31/12/69 - Each year, at least 310 million patients undergo major surgery worldwide, procedures that involve the administration of intravenous fluids. Clinicians have traditionally administered generous amounts of intravenous fluids perioperatively to correct for preoperative fasting and other fluid deficits,…

Case 17-2018: A 40-Year-Old Woman with Leg Swelling and Abdominal Distention and Pain
31/12/69 - Presentation of Case. Dr. Molly E. Wolf (Medicine): A 40-year-old woman was evaluated at this hospital because of progressive edema of the legs, as well as abdominal distention and pain. The patient had been in good health until approximately 10 months before this evaluation, when episodes of pain…

Burosumab Therapy in Children with X-Linked Hypophosphatemia
31/12/69 - X-linked hypophosphatemia, a disorder of renal phosphate wasting and the most common heritable form of rickets, is caused by loss-of-function mutations in the gene encoding phosphate-regulating endopeptidase homolog X-linked (PHEX), which results in excess circulating fibroblast growth factor 23…

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